Amiodarone, verapamil, and quinidine do not affect equilibrium binding of digoxin
RA Colvin, TF Ashavaid, AM Katz… - Journal of …, 1990 - journals.lww.com
… In contrast to their marked effect on steady-state serum digoxin levels when … , quinidine,
verapamil, and amiodarone were without effect on equilibrium binding of [ 3 H]digoxin. Thus, …
verapamil, and amiodarone were without effect on equilibrium binding of [ 3 H]digoxin. Thus, …
Drug interactions with amiodarone
FI Marcus - American heart journal, 1983 - Elsevier
… , verapamil and diltiazem) can further … digoxin and quinidine for a long time before we
appreciated their interaction. Dr. Scheinman: Is the effect of amiodarone caused by protein binding…
appreciated their interaction. Dr. Scheinman: Is the effect of amiodarone caused by protein binding…
Cardiovascular ion channel inhibitor drug-drug interactions with P-glycoprotein
KV Ledwitch, AG Roberts - The AAPS journal, 2017 - Springer
… verapamil, digoxin, and amiodarone. In this review, Pgp-mediated DDIs and their effects
on … renal clearance of quinidine at elevated doses, although digoxin’s effect on the AUC of …
on … renal clearance of quinidine at elevated doses, although digoxin’s effect on the AUC of …
Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor
J Mendell, H Zahir, N Matsushima, R Noveck… - American Journal of …, 2013 - Springer
… Blood samples were collected to determine plasma edoxaban concentrations at serial time
points over 24 h (quinidine, digoxin, and verapamil) or 72 h (amiodarone, atorvastatin, and …
points over 24 h (quinidine, digoxin, and verapamil) or 72 h (amiodarone, atorvastatin, and …
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk …
J Bentz, MP O'Connor, D Bednarczyk… - Drug metabolism and …, 2013 - ASPET
… telmisartan and verapamil, respectively. For telmisartan and verapamil, variability was greatly
… brings the range in IC 50 values for telmisartan and verapamil down to 69- and 159-fold. …
… brings the range in IC 50 values for telmisartan and verapamil down to 69- and 159-fold. …
[PDF][PDF] Clinical Pharmacology of Digoxin in Infants and Children
GM Pacifici - Children, 2021 - medtextpublications.com
… Digoxin verapamil and quinidine are substrates of P-glycoprotein and verapamil and quinidine
inhibit the clearance of digoxin … amiodarone combined with digoxin increases the digoxin …
inhibit the clearance of digoxin … amiodarone combined with digoxin increases the digoxin …
Interaction Between Digoxin and Antiarrhythmic, Diuretic, or Vasodilator Drugs
FI Marcus - … : Selected Problems of Pathogenesis and Clinic, 1983 - Springer
… pharmacokinetic interaction of digoxin with quinidine has been … of digoxin with amiodarone
and with verapamil has been … of digoxin after quinidine was higher than when digoxin was …
and with verapamil has been … of digoxin after quinidine was higher than when digoxin was …
The P-glycoprotein transport system and cardiovascular drugs
JD Wessler, LT Grip, J Mendell, RP Giugliano - Journal of the American …, 2013 - jacc.org
… established that quinidine increased plasma digoxin concentration by … , when amiodarone
is given to a patient taking oral digoxin, … reducing the dose of digoxin when starting verapamil. …
is given to a patient taking oral digoxin, … reducing the dose of digoxin when starting verapamil. …
Standards of laboratory practice: cardiac drug monitoring
R Valdes Jr, SA Jortani, M Gheorghiade - Clinical chemistry, 1998 - academic.oup.com
… verapamil inhibits the biliary and renal elimination of digoxin. … digoxin be measured in
patients currently taking digoxin before treatment with quinidine, amiodarone, or itraconazole is …
patients currently taking digoxin before treatment with quinidine, amiodarone, or itraconazole is …
Pharmacokinetic drug interactions
EA Hartshorn - 1985 - journals.sagepub.com
… is that quinidine displaces digoxin from its binding sites in skeletal (and perhaps cardiac)
muscle, although this explanation is not … drugs that increase digoxin serum levels (amiodarone; …
muscle, although this explanation is not … drugs that increase digoxin serum levels (amiodarone; …